Enclosed Flow Cell Inside the TEM
The TEM Liquid Flow sample holder is the first in-situ liquid-phase TEM platform designed to image nanometer-scale liquid-phase reactions and transformations. Our patented precision-machined chip loading mechanism operates without screws, facilitating reproducible sample loading, self-aligning windows, and stable imaging without drift correction. This simplifies the hardware learning curve, workflows, and micrograph acquisition, guaranteeing reproducible sample preparation and in-situ TEM methodologies.
Advantages:
Designed for Advanced Nanoscale Liquid-phase Dynamics Research
Investigate mechanisms underpinning the dynamics of particle self-assembly, biomineralization and dissolution, corrosion, nanoparticle-MOF structures, temperature-dependent reactions and thin film electrochemistry in liquid environments.
Understand Mechanisms Behind Liquid-Phase Transformations
The transformations that occur at liquid-liquid and solid-liquid interfaces are often nanoscale and highly transient, but nanostructure design is highly dependent on the mechanisms that drive these transformations. The TEM Liquid Flow sample holder applies stimuli such as temperature, electrical bias, light exposure, and liquid mixing to uncover reaction pathways, structural transformations, and degradation mechanisms to develop and characterize the next generation of functional nanostructures.
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Hummingbird Scientific designs, machines, assembles, tests, and services its products in-house. Our integrated engineering, machining, microfabrication, and applications teams enable rapid product development, custom modifications, and direct technical support throughout the life of the instrument. This vertically integrated approach allows researchers to adapt experimental platforms to unique scientific requirements while maintaining the performance and reliability required for advanced in-situ microscopy experiments.
The TEM Liquid Flow sample holder is a direct result of these capabilities, enabling reproducible true bulk electrochemical measurements combined with in-situ nanoscale imaging.
Need something unique? Our engineers can customize existing products or develop entirely new solutions to support specialized experiments and emerging research challenges.
Trusted by researchers worldwide, the Hummingbird Scientific TEM Liquid Flow sample holder has contributed to 30+ peer-reviewed publications from leading universities, national laboratories, and research institutions worldwide in Nature, Science, ACS Nano, Advanced Functional Materials, and other leading journals.
N. de Jonge, D. B. Peckys, G. J. Kremers, D. W. Piston. “Electron microscopy of whole cells in liquid with nanometer resolution”. Proceedings of the National Academy of Sciences (2009)
Achieve reproducible liquid-cell assembly with self-aligning windows and a screw-free sealing design
Simplify cleaning with removable and upgradeable holder tips that allow access for tubing replacement
Image samples in continuous-flow or static liquid environments using a sealed microfluidic chip assembly
Correlate electrochemical, heating, and imaging data across TEM, SEM, and X-ray microscopy platforms
Perform correlative spectroscopy and microscopy for detailed in-situ elemental analysis
Protect your TEM during liquid-cell experiments and streamline setup with rapid high-vacuum seal checking and optical inspection
Keep experiments moving with in-stock liquid-cell TEM chips designed for electrochemistry, liquid flow, heating, and multimodal microscopy workflows
Enhance your in-situ experiments with advanced add-on functionalities
Add temperature-controlled liquid-phase TEM capabilities with homogeneous heating, precise temperature regulation, and near-drift-free in-situ imaging
Accelerate discovery with dual-flow liquid mixing for in-situ liquid phase TEM, capturing dynamic liquid-liquid reactions with greater control and flexibility
The TEM Liquid Flow sample holder integrates a sealed microfluidic cell, user replaceable microfluidic tubing, multi-functional microfabricated substrates, 4 electrical biasing leads, and peripheral control hardware and software into a multi-stimulus liquid-environmental characterization tool. A sample is loaded onto a SiN viewing membrane and sealed inside of the cell. Imaging in the TEM is performed while the solution is circulated through the cell via a microfluidic liquid delivery system. [DA4.1]Dual-inlet tips, biasing leads, and heating/electrochemistry chips enable mixing, thermal, and electrochemical reactions to be imaged in-situ at the nanoscale.
To help you get the most from your liquid-cell holder, Hummingbird Control Software provides intuitive and precise control of closed loop liquid heating. Together, these software solutions enable faster setup, improved reproducibility, and more efficient liquid-phase TEM experiments.
